2025
- Gonella A, Giacomello M, Finos L, Peruffo A (2025) Exposure to PFOS, PFBS, PFOA and PFBA impairs cell cycle progression in bovine brain (Bos taurus) endothelial cells. Res Vet Sci 187:105585 10.1016/j.rvsc.2025.105585
- Norouzi Esfahani E, Knedlik T, Shin SH, Magalhães Rebelo AP, De Mario A, Vianello C, Persano L, Rampazzo E, Edomi P, Bean C, Brunetti D, Scorrano L, Greco S, Gerdol M, Giacomello M (2025) Remodeling of Mitochondria-Endoplasmic Reticulum Contact Sites Accompanies LUHMES Differentiation. Biomolecules 15 10.3390/biom15010126
- Peruffo A, Bassan I, Gonella A, Maccatrozzo L, Otero-Sabio C, Iannuzzi L, Perucatti A, Pistucci R, Giacomello M, Centelleghe C (2025) Establishment and characterization of the Cuvier's beaked whale (Ziphius cavirostris) myogenic cell line. Res Vet Sci 182:105471 10.1016/j.rvsc.2024.105471
2024
2023
- Bomfim GHS, Giacomello M, Lacruz RS (2023) PMCA Ca(2+) clearance in dental enamel cells depends on the magnitude of cytosolic Ca(2). FASEB J 37:e22679 10.1096/fj.202201291R
- Chemello F, Pozzobon M, Tsansizi LI, Varanita T, Quintana-Cabrera R, Bonesso D, Piccoli M, Lanfranchi G, Giacomello M, Scorrano L, Bean C (2023) Dysfunctional mitochondria accumulate in a skeletal muscle knockout model of Smn1, the causal gene of spinal muscular atrophy. Cell Death Dis 14:162 10.1038/s41419-023-05573-x
- Di Donfrancesco A, Berlingieri C, Giacomello M, Frascarelli C, Magalhaes Rebelo AP, Bindoff LA, Reeval S, Renbaum P, Santorelli FM, Massaro G, Viscomi C, Zeviani M, Ghezzi D, Bottani E, Brunetti D (2023) PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients. Front Pharmacol 14:1220620 10.3389/fphar.2023.1220620
- Muccioli S, Brillo V, Varanita T, Rossin F, Zaltron E, Velle A, Alessio G, Angi B, Severin F, Tosi A, D'Eletto M, Occhigrossi L, Falasca L, Checchetto V, Ciaccio R, Fascì A, Chieregato L, Rebelo AP, Giacomello M, Rosato A, Szabò I, Romualdi C, Piacentini M, Leanza L (2023) Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma. Cell Death Dis 14:704 10.1038/s41419-023-06223-y
- Vianello C, Dal Bello F, Shin SH, Schiavon S, Bean C, Magalhães Rebelo AP, Knedlík T, Esfahani EN, Costiniti V, Lacruz RS, Covello G, Munari F, Scolaro T, Viola A, Rampazzo E, Persano L, Zumerle S, Scorrano L, Gianelle A, Giacomello M (2023) High-Throughput Microscopy Analysis of Mitochondrial Membrane Potential in 2D and 3D Models. Cells 12 10.3390/cells12071089
2022
- Costiniti V, Bomfim GHS, Neginskaya M, Son GY, Mitaishvili E, Giacomello M, Pavlov E, Lacruz RS (2022) Mitochondria modulate ameloblast Ca(2+) signaling. FASEB J 36:e22169 10.1096/fj.202100602R
- Otero-Sabio C, Giacomello M, Centelleghe C, Caicci F, Bonato M, Venerando A, Graïc JM, Mazzariol S, Finos L, Corain L, Peruffo A (2022) Cell cycle alterations due to perfluoroalkyl substances PFOS, PFOA, PFBS, PFBA and the new PFAS C6O4 on bottlenose dolphin (Tursiops truncatus) skin cell. Ecotoxicol Environ Saf 244:113980 10.1016/j.ecoenv.2022.113980
- van der Kooij MA, Rojas-Charry L, Givehchi M, Wolf C, Bueno D, Arndt S, Tenzer S, Mattioni L, Treccani G, Hasch A, Schmeisser MJ, Vianello C, Giacomello M, Methner A (2022) Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. J Mol Med (Berl) 100:1441-1453 10.1007/s00109-022-02235-x
- Wolf C, Pouya A, Bitar S, Pfeiffer A, Bueno D, Rojas-Charry L, Arndt S, Gomez-Zepeda D, Tenzer S, Bello FD, Vianello C, Ritz S, Schwirz J, Dobrindt K, Peitz M, Hanschmann EM, Mencke P, Boussaad I, Silies M, Brüstle O, Giacomello M, Krüger R, Methner A (2022) GDAP1 loss of function inhibits the mitochondrial pyruvate dehydrogenase complex by altering the actin cytoskeleton. Commun Biol 5:541 10.1038/s42003-022-03487-6
- Zamberlan M, Boeckx A, Muller F, Vinelli F, Ek O, Vianello C, Coart E, Shibata K, Christian A, Grespi F, Giacomello M, Struman I, Scorrano L, Herkenne S (2022) Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth. J Exp Clin Cancer Res 41:95 10.1186/s13046-022-02304-6
2021
- Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L (2021) Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep 34:108873 10.1016/j.celrep.2021.108873
- Corrado M, Samardžić D, Giacomello M, Rana N, Pearce EL, Scorrano L (2021) Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism. Cell Death Differ 28:2194-2206 10.1038/s41418-021-00747-6
2020
- Cerqueira FM, von Stockum S, Giacomello M, Goliand I, Kakimoto P, Marchesan E, De Stefani D, Kowaltowski AJ, Ziviani E, Shirihai OS (2020) A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake. Redox Biol 37:101676 10.1016/j.redox.2020.101676
- Costiniti V, Bomfim GH, Li Y, Mitaishvili E, Ye ZW, Zhang J, Townsend DM, Giacomello M, Lacruz RS (2020) Mitochondrial Function in Enamel Development. Front Physiol 11:538 10.3389/fphys.2020.00538
- Giacomello M, Pyakurel A, Glytsou C, Scorrano L (2020) The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21:204-224 10.1038/s41580-020-0210-7
- Herkenne S, Ek O, Zamberlan M, Pellattiero A, Chergova M, Chivite I, Novotná E, Rigoni G, Fonseca TB, Samardzic D, Agnellini A, Bean C, Di Benedetto G, Tiso N, Argenton F, Viola A, Soriano ME, Giacomello M, Ziviani E, Sales G, Claret M, Graupera M, Scorrano L (2020) Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. Cell Metab 31:987-1003.e8 10.1016/j.cmet.2020.04.007
- Magalhães Rebelo AP, Dal Bello F, Knedlik T, Kaar N, Volpin F, Shin SH, Giacomello M (2020) Chemical Modulation of Mitochondria-Endoplasmic Reticulum Contact Sites. Cells 9 10.3390/cells9071637
- Vascon F, Gasparotto M, Giacomello M, Cendron L, Bergantino E, Filippini F, Righetto I (2020) Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design. Comput Struct Biotechnol J 18:1774-1789 10.1016/j.csbj.2020.06.029
- Vianello C, Cocetta V, Caicci F, Boldrin F, Montopoli M, Martinuzzi A, Carelli V, Giacomello M (2020) Interaction Between Mitochondrial DNA Variants and Mitochondria/Endoplasmic Reticulum Contact Sites: A Perspective Review. DNA Cell Biol 39:1431-1443 10.1089/dna.2020.5614
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Selected papers from the past
- Larrea D, Pera M, Gonnelli A, Quintana-Cabrera R, Akman HO, Guardia-Laguarta C, Velasco KR, Area-Gomez E, Dal Bello F, De Stefani D, Horvath R, Shy ME, Schon EA, Giacomello M (2019) MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics. Hum Mol Genet 28:1782-1800 10.1093/hmg/ddz008
- Cieri D, Vicario M, Giacomello M, Vallese F, Filadi R, Wagner T, Pozzan T, Pizzo P, Scorrano L, Brini M, Calì T (2018) SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition. Cell Death Differ 25:1131-1145 10.1038/s41418-017-0033-z
- Ilacqua N, Sánchez-Álvarez M, Bachmann M, Costiniti V, Del Pozo MA, Giacomello M (2017) Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions. Front Cell Dev Biol 5:107 10.3389/fcell.2017.00107
- Rosselin M, Santo-Domingo J, Bermont F, Giacomello M, Demaurex N (2017) L-OPA1 regulates mitoflash biogenesis independently from membrane fusion. EMBO Rep 18:451-463 10.15252/embr.201642931
- Giacomello M, Pellegrini L (2016) The coming of age of the mitochondria-ER contact: a matter of thickness. Cell Death Differ 23:1417-27 10.1038/cdd.2016.52
- Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L (2016) Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A 113:11249-11254 10.1073/pnas.1606786113
- Sala-Vila A, Navarro-Lérida I, Sánchez-Alvarez M, Bosch M, Calvo C, López JA, Calvo E, Ferguson C, Giacomello M, Serafini A, Scorrano L, Enriquez JA, Balsinde J, Parton RG, Vázquez J, Pol A, Del Pozo MA (2016) Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice. Sci Rep 6:27351 10.1038/srep27351
- Zanetti F, Giacomello M, Donati Y, Carnesecchi S, Frieden M, Barazzone-Argiroffo C (2014) Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free Radic Biol Med 76:173-84 10.1016/j.freeradbiomed.2014.08.002
- Giacomello M, Oliveros JC, Naranjo JR, Carafoli E (2013) Neuronal Ca(2+) dyshomeostasis in Huntington disease. Prion 7:76-84 10.4161/pri.23581
- Santo-Domingo J, Giacomello M, Poburko D, Scorrano L, Demaurex N (2013) OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J 32:1927-40 10.1038/emboj.2013.124
- Scorzeto M, Giacomello M, Toniolo L, Canato M, Blaauw B, Paolini C, Protasi F, Reggiani C, Stienen GJ (2013) Mitochondrial Ca2+-handling in fast skeletal muscle fibers from wild type and calsequestrin-null mice. PLoS One 8:e74919 10.1371/journal.pone.0074919
- Canato M, Scorzeto M, Giacomello M, Protasi F, Reggiani C, Stienen GJ (2010) Massive alterations of sarcoplasmic reticulum free calcium in skeletal muscle fibers lacking calsequestrin revealed by a genetically encoded probe. Proc Natl Acad Sci U S A 107:22326-31 10.1073/pnas.1009168108
- Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L (2010) Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med 2:490-503 10.1002/emmm.201000102
- Giacomello M, Drago I, Bortolozzi M, Scorzeto M, Gianelle A, Pizzo P, Pozzan T (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol Cell 38:280-90 10.1016/j.molcel.2010.04.003
- Drago I, Giacomello M, Pizzo P, Pozzan T (2008) Calcium dynamics in the peroxisomal lumen of living cells. J Biol Chem 283:14384-90 10.1074/jbc.M800600200
- Giacomello M, Drago I, Pizzo P, Pozzan T (2007) Mitochondrial Ca2+ as a key regulator of cell life and death. Cell Death Differ 14:1267-74 10.1038/sj.cdd.4402147
- Palmer AE, Giacomello M, Kortemme T, Hires SA, Lev-Ram V, Baker D, Tsien RY (2006) Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs. Chem Biol 13:521-30 10.1016/j.chembiol.2006.03.007
- Giacomello M, Barbiero L, Zatti G, Squitti R, Binetti G, Pozzan T, Fasolato C, Ghidoni R, Pizzo P (2005) Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia. Neurobiol Dis 18:638-48 10.1016/j.nbd.2004.10.016